Sunday, December 12, 2004

A vision for the future of genomics research

Of particular interest, if all the mammalian genome is considerably similar from one animal to another then the detailed mouse genome can be used to define any sequence we seeek to change. If I choose to change a particular sequence, then this mouse map will help me find where the changes should ocurr. This should prove to be fun!

The practical consequences of the emergence of this new field are widely apparent. Identification of the genes responsible for human mendelian diseases, once a herculean task requiring large research teams, many years of hard work, and an uncertain outcome, can now be routinely accomplished in a few weeks by a single graduate student with access to DNA samples and associated phenotypes, an Internet connection to the public genome databases, a thermal cycler and a DNA-sequencing machine. With the recent publication of a draft sequence of the mouse genome11, identification of the mutations underlying a vast number of interesting mouse phenotypes has similarly been greatly simplified. Comparison of the human and mouse sequences shows that the proportion of the mammalian genome under evolutionary selection is more than twice that previously assumed.

When scientists compared the human and mouse genomes, they discovered that more than 90 percent of the mouse genome could be lined up with a region on the human genome.
genome.gov2002 Release The Mouse Genome And The Measure of Man: "Such research will have profound long-term consequences for medicine. It will help elucidate the underlying molecular mechanisms of disease. This in turn will allow researchers to design better drugs and therapies for many illnesses.
'The mouse genome is a great resource for basic and applied medical research, meaning that much of what was done in a lab can now be done through the Web. Researchers can access this information through, where all the information is provided with no restriction,' says Ewan Birney, Ph.D., Ensembl coordinator at the European Bioinformatics Institute."

1 comment:

stars2man said...

Ensembl Mouse Genome Server: "Mouse Genome Assembly NCBI m33

This site provides a full Ensembl gene build for the NCBI m33 mouse assembly (freeze May 27, 2004, strain C57BL/6J). After extensive QC from both the Sanger Institute and NCBI, most artefactual assembly issues introduced in build m32 have been removed. The whole genome N50 is 22.3 Mb. (Build m32 was 17.7 Mb).

New software systems have improved the gene set. More than 85% of genes from build m32 retain the same Ensembl gene ids in this release. New gene identifiers were assigned where a many-to-one or many-to-many mapping of old genes to new gene structures was detected.

Patches to this build will be provided regularly as more detailed analysis is performed.

Mouse sequencing project credits
Additional mouse resources
Top 40 InterPro domains
The mouse physical map has been published in Nature
MGSC newsletter pdfs "